For adults with sort 2 diabetes and weight problems, glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are related to a decrease threat for dementia, stroke, and all-cause mortality in contrast with different antidiabetic medication, based on a research printed on-line July 15 in JAMA Community Open.
Huan-Tang Lin, M.D., Ph.D., from Chang Gung Memorial Hospital at Linkou in Taiwan, and colleagues examined the affiliation of semaglutide and tirzepatide with the incidence of dementia, Parkinson illness, ischemic stroke, intracerebral hemorrhage, and all-cause mortality in comparison with different antidiabetic medication in a retrospective cohort research analyzing digital well being record-based knowledge for adults aged 40 years or older with sort 2 diabetes and weight problems.
The research included 60,860 adults with sort 2 diabetes and weight problems: 30,430 within the GLP-1 RA group and 30,430 within the different antidiabetic drug group (biguanides, sulfonylureas, dipeptidyl peptidase 4 inhibitors, sodium-glucose cotransporter 2 inhibitors, thiazolidinediones, and α-glucosidase inhibitors) after propensity rating matching.
The researchers discovered that GLP-1 RA customers had a decrease threat for dementia, ischemic stroke, and all-cause mortality throughout a seven-year follow-up (hazard ratios, 0.63, 0.81, and 0.70, respectively), whereas no important variations had been seen within the dangers for Parkinson illness or intracerebral hemorrhage. Higher advantages had been seen for these aged 60 years or older, ladies, and sufferers with a physique mass index of 30 to 40 kg/m2.
“These findings highlight the possible role of GLP-1 RAs in mitigating neurodegenerative and cerebrovascular risks in this high-risk population,” the authors write.
Extra data:
Huan-Tang Lin et al, Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Sufferers With Diabetes and Weight problems, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.21016
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Threat for dementia, ischemic stroke, mortality decrease with GLP-1 receptor agonists in sort 2 diabetes, weight problems (2025, July 22)
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