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Folks with an underactive thyroid might have an elevated threat of growing small intestinal bacterial overgrowth (SIBO), a threat which may be lowered with thyroid hormone remedy, based on a research being introduced Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
“We now know that people with hypothyroidism, especially those with autoimmune thyroiditis, are more likely to develop SIBO, but this risk appears to be mitigated in those taking thyroid medications,” mentioned Ruchi Mathur, M.D., Director of the Diabetes Outpatient Therapy and Training Middle and Director of Medical Operations of Medically Related Science and Expertise, at Cedars-Sinai in Los Angeles, Calif.
Mathur mentioned their analysis additionally suggests there could also be a microbiological mechanism driving this affiliation, which may result in extra personalised remedies.
The researchers investigated the connection between SIBO and hypothyroidism in individuals older than 18 who beforehand underwent higher endoscopy with out colon prep and reported residing with hypothyroidism in addition to controls. Topics had been recruited by way of their flagship REIMAGINE research.
They analyzed small bowel fluid samples from 49 individuals with hypothyroidism and 323 with out the situation and carried out DNA sequencing to determine microbial species. The outcomes confirmed that folks with hypothyroidism had a considerably larger prevalence of SIBO in comparison with controls (33% vs. 15%).
Mathur and colleagues then additional evaluated 4 teams: SIBO-positive with hypothyroidism, SIBO-negative with hypothyroidism, SIBO-positive with out thyroid illness, and SIBO-negative with out thyroid illness.
The evaluation confirmed completely different patterns of micro organism within the intestine relying on an individual’s thyroid standing and co-occurrence of SIBO.
Individually, they carried out a large-scale evaluation of medical information from the TriNetX database, which seemed on the 10-year dangers of growing SIBO in individuals with hypothyroidism or autoimmune thyroiditis in comparison with matched controls. The dangers had been additionally mitigated in individuals taking levothyroxine.
“Results showed the risk of developing SIBO in subjects with hypothyroidism is 2.2 times more than the risk in a matched control cohort and was 2.4 times higher in those with autoimmune thyroiditis compared to a matched control group. This echoes our findings in the REIMAGINE cohort,” famous the research’s presenting creator, Margaret Wei, M.D., of the Cedars-Sinai Medical Middle Endocrine Fellowship Program.
“These findings open the door to new screening and prevention strategies. For example, doctors may begin to monitor thyroid health more closely in patients with SIBO, and vice versa. It also supports the idea that improving gut health could have far-reaching effects beyond digestion, possibly even helping to prevent autoimmune diseases, such as Hashimoto’s,” Mathur mentioned. “As research continues, this could lead to more personalized care and earlier interventions for at-risk individuals.”
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Thyroid remedy might enhance intestine well being in individuals with hypothyroidism (2025, July 12)
retrieved 12 July 2025
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