The composite gel will be injected straight into the postresection cavity after tumor bulk excision to attain native drug supply. The tissue adhesive property of the gel makes it extra adaptable to the surgical cavity and able to delivering the therapeutic brokers to the infiltrative glioma tissue. Credit score: Chemical Engineering Journal (2025). DOI: 10.1016/j.cej.2025.167569
Excessive-grade gliomas are aggressive mind tumors with poor prognosis, largely as a result of even after surgical elimination, infiltrative residual tumor cells usually regrow through the latency earlier than radiotherapy, resulting in recurrence. The usual chemoradiotherapy solely modestly improves survival. A vital window of vulnerability arises post-surgery, earlier than radiotherapy begins, the place residual tumor cells usually are not properly addressed by systemic chemotherapy.
Prof. Feng-Huei Lin and Dr. Jason Lin from Nationwide Taiwan College have designed a neighborhood post-surgical gel packing with sequential supply of platinum brokers that might preserve therapeutic drug concentrations intracranially and synergize with subsequent radiotherapy to eradicate glioma tissue. Their research is revealed within the Chemical Engineering Journal.
The cutting-edge drug-delivery gel will be straight injected into the surgical cavity following tumor resection. This gel supplies sustained native supply of platinum-based anticancer brokers, making certain efficient eradication for residual glioma tissue that stay after surgical procedure. The gel is designed to maximise the therapeutic influence whereas minimizing systemic publicity.
Sequential platinum supply system
The gel makes use of a sequential supply system to maximise its effectiveness. The primary stage includes the instant launch of carboplatin, a platinum-based chemotherapy drug, which suppresses remaining glioma cells proper after surgical procedure. The second stage includes platinum-doped calcium carbonate (CaCO₃:Pt) particles, which launch platinum brokers extra steadily. This delayed launch happens intracellularly by way of endocytosis, making certain that the therapeutic impact continues over time earlier than subsequent radiotherapy.
It was demonstrated that the gel induces important apoptosis in glioma cells by inflicting substantial DNA injury (DNA double strand break), which is the important mechanism for combating most cancers.
When examined in orthotopic mind tumor fashions, the place tumors are implanted straight into the mind, the gel, mixed with radiotherapy, considerably suppressed tumor relapse. This mixture therapy method enhances the efficacy of radiotherapy whereas making certain that the chemotherapy brokers are delivered on to the tumor website.
Lowering radiation dose whereas enhancing effectiveness
One of the vital promising features of this composite gel is its skill to scale back the required dose of radiotherapy. By enhancing the native effectiveness of the chemotherapy and bettering the sensitivity of tumor cells to radiation, the gel permits for the usage of decrease doses of radiotherapy.
Analysis scientist Dr. Jason Lin from Division of Biomedical Engineering, Nationwide Taiwan College, the research’s first writer, mentioned, “This approach not only boosts treatment efficacy but also minimizes the side effects associated with higher doses of radiation, ultimately leading to a safer and more effective treatment regimen.”
Principal investigator Prof. Feng-Huei Lin from Division of Biomedical Engineering, Nationwide Taiwan College, mentioned, “Our findings show that the postoperatively injected gel, designed for sequential delivery of platinum-based agents, can significantly enhance radiotherapy outcomes and effectively reduce the risk of high-grade glioma relapse.”
Extra info:
Jason Lin et al, Postoperatively injected gel with sequential supply of platinum brokers to synergize with radiotherapy for suppressing high-grade glioma relapse, Chemical Engineering Journal (2025). DOI: 10.1016/j.cej.2025.167569
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Time-released gel packs a one-two punch towards aggressive mind tumors (2025, September 26)
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