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Train is understood for the constructive results on metabolic ailments, partly due to the discharge of circulating extracellular vesicles (EVs) that mediate intercellular communication and organ crosstalk.
In a brand new doctoral thesis from Karolinska Institutet, Zhenghao Wang, doctoral pupil on the Division of Molecular Drugs and Surgical procedure, explores the molecular composition and biofunction of exercise-induced EVs, specializing in their function in well being advantages and pancreatic β-cell safety.
What’s the primary focus of your thesis?
“The aim of my thesis is to investigate the potential positive regulatory roles of exercise-induced circulating extracellular vesicles in pancreatic β-cell function and survival, and explore its underlying molecular mechanisms,” says Wang, doctoral pupil on the Sign Transduction analysis group, Division of Molecular Drugs and Surgical procedure, Karolinska Institutet.
That are an important outcomes?
“This study reveals that exercise systemically improves diabetes by triggering a multi-organ exosomal network, moving beyond traditional single-organ perspectives and providing novel systemic insights. We identify exercise-induced exosomal miR-124 as a key regulator of endoplasmic reticulum stress (ERS), bridging exercise to cytoprotection in diabetes and offering a novel therapeutic candidate.”
How can this new data contribute to the advance of individuals’s well being?
“By identifying exosomal miR-124 as a key mediator, we can develop targeted exercise regimens optimized for diabetes prevention and treatment, particularly for high-risk individuals. Blood tests measuring miR-124 levels could help track therapeutic responses. Engineered exosomes or synthetic miR-124 mimics could be developed as injectable ‘exercise mimetics,’ offering benefits for diabetic patients who cannot engage in physical activity due to mobility limitations or other health complications.”
What are your future ambitions?
“Our goal is to transform exercise biology into tangible solutions, moving from mechanistic insights to diagnostics, therapeutics, and equitable health innovations that combat diabetes and beyond,” says Wang.
Extra data:
Zhenghao Wang, Train-induced extracellular vesicles and their protecting function towards diabetes (2025). DOI: 10.69622/30022921.v1
Offered by
Karolinska Institutet
Quotation:
Train-induced vesicles assist defend pancreatic cells and guard towards diabetes (2025, October 28)
retrieved 28 October 2025
from https://medicalxpress.com/information/2025-10-vesicles-pancreatic-cells-diabetes.html
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