Receiving two doses of inactivated influenza vaccine (IIV) within the first yr of influenza vaccination is related to improved safety for youngsters youthful than 3 years versus one dose, in keeping with a research revealed on-line Oct. 3 in JAMA Community Open.
Jessie J. Goldsmith, from College of Melbourne in Australia, and colleagues carried out a scientific literature assessment to estimate the rise in safety related to the second dose of influenza vaccine for influenza vaccine-naive youngsters youthful than 9 years.
Primarily based on 51 research (415,050 members), the researchers discovered that the pooled absolute enhance in vaccine effectiveness of a second inactivated influenza vaccine dose within the first yr of vaccination was 15 proportion factors (pp) for these youthful than 9 years (95% confidence interval [CI], −2.8 pp to 33 pp) and 28 pp (95% CI, 4.7 pp to 51 pp) for youngsters youthful than 3 years. It was not doable to evaluate the incremental profit related to a second dose of reside attenuated influenza vaccine.
“Our findings recommend the second dose of inactivated influenza vaccine confers extra safety for influenza vaccine-naive youngsters
Extra data:
Jessie J. Goldsmith et al, Comparability of two Doses vs 1 Dose within the First Season Kids Are Vaccinated Towards Influenza, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.35250
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Two flu vaccine doses increase profit for youngsters youthful than 3 years (2025, October 17)
retrieved 17 October 2025
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