Vitamin D deficiency (VDD) is independently related to elevated despair danger in sufferers with power kidney illness (CKD), in accordance with a examine revealed on-line Jan. 26 in Frontiers in Diet.
I-Wen Chen, from Chi Mei Medical Middle in Tainan Metropolis, Taiwan, and colleagues examined the affiliation between VDD and the danger for despair. The evaluation included 17,955 propensity-matched pairs of sufferers with CKD (aged 50 years and older) with VDD of ≤20 ng/mL or ≥30 ng/mL (management group), as measured inside three months of CKD analysis.
The researchers discovered that VDD was related to elevated despair danger at one yr (hazard ratio [HR], 1.929). This affiliation remained at follow-up three years later. The discovering was constant throughout CKD levels, with comparable dangers in early CKD (HR, 1.977) and CKD stage 3 to five (HR, 1.981). Despair danger was larger amongst males with VDD (HR, 2.264) versus girls (HR, 1.761). Larger despair danger was seen even with vitamin D insufficiency (20 to 30 ng/mL) versus regular ranges (HR, 1.667).
“These findings suggest that maintaining adequate vitamin D levels might be important for mental health in patients with CKD, although randomized trials are needed to confirm whether supplementation can prevent depression in this population,” the authors write.
Extra info:
I-Wen Chen et al, Affiliation between vitamin D deficiency and main despair in sufferers with power kidney illness: a cohort examine, Frontiers in Diet (2025). DOI: 10.3389/fnut.2025.1540633
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Vitamin D deficiency tied to despair danger with power kidney illness (2025, February 25)
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