For girls with newly identified invasive breast most cancers (BC), weight acquire is related to an elevated danger for coronary heart failure, based on a analysis letter revealed on-line Jan. 9 in JAMA Oncology.
Wonyoung Jung, M.D., Ph.D., from the Perelman Faculty of Medication on the College of Pennsylvania in Philadelphia, and colleagues examined the affiliation between weight modifications and coronary heart failure danger after BC improvement utilizing the Nationwide Well being Insurance coverage Service database of the Republic of Korea. The cohort included 43,717 ladies newly identified with invasive BC with out prior coronary heart failure earlier than or inside one 12 months of prognosis. Weight change was assessed from screenings earlier than (zero to 2 years) and after (0.5 to 2.5 years) BC prognosis and was categorised primarily based on share modifications.
The researchers discovered that 6.1, 15.7, 63.9, 10.7, and three.5% of sufferers had greater than 10% weight reduction, had 5 to 10% weight reduction, maintained weight, had 5 to 10% weight acquire, and had greater than 10% weight acquire, respectively.
After adjusting for cardiovascular danger components, most cancers therapy, and sociodemographic components, 5 to 10% weight acquire was related to an elevated danger for coronary heart failure (adjusted hazard ratio, 1.59) and greater than 10% weight acquire was related to additional elevated danger (adjusted hazard ratio, 1.85) in contrast with weight maintainers throughout a imply follow-up of 4.67 years. There was no affiliation seen for weight reduction with coronary heart failure danger.
“The findings underscore the importance of effective weight intervention in the oncological care of patients with BC, particularly within the first few years after diagnosis, to protect cardiovascular health,” the authors write.
Extra info:
Wonyoung Jung et al, Weight Adjustments and Coronary heart Failure Danger After Breast Most cancers Improvement, JAMA Oncology (2025). DOI: 10.1001/jamaoncol.2024.5803
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