Physique mass index (BMI) and bodily exercise are related to the danger for subsequent neoplasms amongst childhood most cancers survivors, in accordance with a examine revealed on-line June 5 in JAMA Oncology.
Lenat Joffe, M.D., from Northwell in New Hyde Park, New York, and colleagues examined associations between time-varying BMI/bodily exercise and subsequent neoplasm danger amongst childhood most cancers survivors in a retrospective cohort evaluation. 5-year childhood most cancers survivors recognized at youthful than 21 years of age between 1970 and 1999 had been enrolled and adopted by means of September 2019.
Total, 22,716 members had BMI knowledge earlier than subsequent neoplasm growth and met eligibility standards for the examine. The researchers discovered 2,554 subsequent neoplasms amongst 2,156 people (median age at subsequent neoplasm analysis, 37.4 years).
Larger 30-year subsequent neoplasm cumulative incidence was seen for survivors reporting decrease bodily exercise (18.6% for 0 metabolic equal hours/week [MET-h/wk] versus 10.9% for 15 to 21 MET-h/wk). Overweight BMI was related to elevated incidence charges of stable organ, central nervous system (CNS), and pores and skin subsequent neoplasms (relative charges, 1.22, 1.47, and 1.30, respectively).
A protecting affiliation was seen for increased bodily exercise (15 to 21 MET-h/wk) for any stable organ, CNS, and pores and skin subsequent neoplasms (relative charges, 0.61, 0.65, 0.50, and 0.72, respectively). Particular associations had been seen for BMI and bodily exercise with subsequent meningiomas and thyroid carcinomas, however not with breast or colorectal cancers or hematologic subsequent neoplasms.
“The findings of this cohort study indicated that BMI and physical activity may considerably impact subsequent neoplasm risk long after completion of therapy,” the authors write.
Two authors disclosed ties to the biopharmaceutical and medical gadget industries.
Extra data:
Lenat Joffe et al, Physique Mass Index, Bodily Exercise, and Subsequent Neoplasm Danger Amongst Childhood Most cancers Survivors, JAMA Oncology (2025). DOI: 10.1001/jamaoncol.2025.1340
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Weight problems linked to subsequent neoplasms in childhood most cancers survivors (2025, June 6)
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