YF17D vaccination induces frequent and distinct time-dependent transcriptome modifications in blood APC subpopulations. Credit score: Elena Winheim et al
The yellow fever vaccination utilizing the live-attenuated YF17D vaccine is among the simplest immunizations out there. A single dose gives long-lasting safety towards the illness.
As a result of power and long-lasting nature of the immune response it triggers, this vaccine serves as a superb mannequin for learning efficient immune protection mechanisms towards viral infections. Nevertheless, it’s nonetheless not absolutely understood how precisely this vaccine elicits such an exceptionally robust immune response.
A staff led by immunology professor Anne Krug at LMU’s Biomedical Middle (BMC) in collaboration with Simon Rothenfußer, professor at LMU College Hospital, has investigated how particular immune cells—particularly dendritic cells (DCs) and monocytes—reply to the vaccine.
A very hanging discovering was the cell floor molecule SIGLEC-1, which grew to become extra outstanding on sure cell varieties inside one week of vaccination and was related to the fast formation of protecting antibodies towards the yellow fever virus. The examine is printed within the Proceedings of the Nationwide Academy of Sciences.
“Our study provides new insights into how the immune system responds to a highly effective viral vaccine,” says Krug. “These findings could support the development of new vaccines that offer rapid protection, for example in the context of emerging epidemics. Additionally, SIGLEC-1 may serve as a useful biomarker in future vaccine studies.”
Extra data:
Elena Winheim et al, Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses, Proceedings of the Nationwide Academy of Sciences (2025). DOI: 10.1073/pnas.2422236122
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Ludwig Maximilian College of Munich
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Yellow fever vaccination: How robust immune responses are triggered (2025, Might 14)
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